MePiA and MePA Intake Recommendations

September 24, 2019 Update
by Gerald E. Aardsma, Ph.D.

The drop size for the dropper bottle used with Dr. Aardsma’s Anti-Aging Vitamins dietary supplement has now been found to be 20% smaller than expected. As a result of this smaller drop size, the bottle contains more drops than expected, but each drop provides just 0.8 microgram of MePiA and 0.8 microgram of MePA instead of the intended 1.0 microgram of each per drop. This gives a 20% lower daily intake than intended. The table below increases the number of drops recommended per day to correct for this smaller drop size.

Table 1. Estimated daily intake of Dr. Aardsma’s Anti-Aging Vitamins dietary supplement rounded to the nearest drop.
 Category  Male  Female 
Age, years  
19 and older86
Reproductive Status  
Pregnant 6
Breast-feeding 8

This change does not affect the actual amount of the anti-aging vitamins in the bottle, so it does not affect how long the bottle will last an individual taking the recommended daily microgram amounts of these vitamins.

July 30, 2019 Update
by Matthew Aardsma, Ph.D.


Determination of the optimal daily intake for vitamins is no trivial task. Scientists today are still working to fine-tune the daily recommended intake of vitamins discovered several generations ago. The empirical determination of the optimal daily intake for vitamin MePA is also not a trivial undertaking, and has been a key priority for Aardsma Research & Publishing (ARP) for the last several years. In the meantime, ARP has felt a responsibility to keep people updated with the most current information so they can make the best informed decision about how much vitamin MePA to consume. To fill this need, ARP has periodically summarized and presented the current evidence. The most recent of these reports is the February 26, 2019 update. I would encourage those unfamiliar with the February 26 update to read it. The framework of evidence presented in that update is still the fundamental basis of the estimated daily intake information presented in this update.

The reason for the present update to the daily intake information is that Dr. Aardsma’s Vitamin MePA Dietary Supplement is being replaced by a new supplement, Dr. Aardsma’s Anti-Aging Vitamins. The new supplement now includes both vitamin MePA and a new molecule, methylphosphinic acid (MePiA). MePiA is the reduced form of MePA, which means MePiA is the same as MePA except that it has one less oxygen atom than MePA. Both MePA and MePiA would have been present in drinking water before Noah’s Flood, as they were both naturally produced in the environment from methylphosphine gas prior to the Flood. Recent evidence from the ARP research program has revealed that both MePA and MePiA are needed in the diet for modern humans to enjoy the health and longevity experienced by people living before Noah’s Flood. MePA and MePiA both appear to be vitamins. You might think of MePA and MePiA as the anti-aging vitamin duo. You can read about the discovery of vitamin MePiA in the Addendum to Aging: Cause and Cure.

Estimated Daily Intake of the Anti-Aging Duo

The estimation of the daily need for MePA has not changed since the February 26 update, and, for now, the assumption is being made that the physiological need for MePiA is similar to that of the need for MePA. What has changed is that the new supplement, Dr. Aardsma’s Anti-Aging Vitamins, now has 1 microgram of MePA per drop, rather than 2 micrograms, together with 1 microgram of MePiA per drop. This change requires a different number of drops to obtain the same amount of MePA per day as was being obtained from Dr. Aardsma’s Vitamin MePA Dietary Supplement. This change gives rise to the new estimated intake values shown in Table 1. Since the results of both the present Table 1 and the February 26 update Table 1 are rounded to the nearest drop, the results of the new table are not exactly double the previously given intake rate in the old table. The bottle for Dr. Aardsma’s Anti-Aging Vitamins supplement is larger than the bottle used for Dr. Aardsma’s Vitamin MePA Dietary Supplement, and contains approximately 360 drops.

Table 1. Estimated daily intake of Dr. Aardsma’s Anti-Aging Vitamins dietary supplement rounded to the nearest drop.
 Category  Male  Female 
Age, years  
19 and older64
Reproductive Status  
Pregnant 5
Breast-feeding 6

It is expected that revisions to the daily intake guidelines will occur as research to establish the optimal intake of MePA (and now MePiA) continues to be a major priority for ARP. Also, note that the intake information presented in this update applies only to Dr. Aardsma’s Anti-Aging Vitamins supplement. The evidence is clear that both MePA and MePiA are required to optimally combat aging, therefore, Dr. Aardsma’s Vitamin MePA Dietary Supplement (which only provided MePA) is no longer available.

How to Use This Information

This information is given to help individuals desiring to take Dr. Aardsma’s Anti-Aging Vitamins make an informed decision regarding what amount to consume. This is not meant to be a definitive guide, nor is it intended to supplant the advice of a medical or nutritional professional.

See the February 26 update for in-depth details on the reasoning behind the calculated intake rates found in Table 1. An expanded discussion is presented here for a few categories only.

Infants and Toddlers

It is assumed that pre-Flood mothers would have nursed their babies through the toddler stage as is common in cultures not impacted by technologies such as infant formula and prepared baby food. Since MePA and MePiA are both water-soluble, it is believed that both MePA and MePiA were likely passed from the mother to the infant or toddler in breast-milk pre-Flood. Therefore, any need of the infant or toddler for MePA and MePiA would have been met simply by nursing. As the toddler began to wean and consume drinking water, the dietary supply would have shifted away from the mother’s milk and towards water intake. The calculated intake levels from Table 1 artificially assume that weaning is an abrupt event complete by age 4. This oversimplification is why the supplementation rate increases from 0 drops per day from age 0 to 3 years to 3 drops per day at age 4. Since weaning is typically a more gradual process, a slow increase in Dr. Aardsma’s Anti-Aging Vitamins intake concomitant with a gradual decrease in nursing may more closely replicate what children experienced pre-Flood.

Children and Teens

“Do children and teenagers need to consume anti-aging vitamins? After all, they have decades before the effects of aging even begin to catch up with them.”

This is a great question. The answer appears to be a pretty firm yes. It comes in two parts.

  1. It was Nature’s time-tested practice. Since MePA and MePiA were naturally distributed through the environment to pre-Flood people in rain water, the natural system would have provided MePA and MePiA to everyone drinking water. If we desire to mimic that pre-Flood system (which is the only system we know of that has enabled people to live healthy and productive lives spanning hundreds of years) then children old enough to need water should be getting MePA and MePiA.
  2. Physiological damage due to “aging” is happening to everyone, not just elderly people. ARP believes that at least part of the physiological basis for the effectiveness of Dr. Aardsma’s Anti-Aging Vitamins is that damage due to free radicals (also called reactive oxygen species) within the body is reduced. This is in line with the free radical theory of aging, which is an established theory of aging advocated by Denham Harman (MD, PhD) roughly 50 years ago. Free radicals are produced in small amounts as a by-product of normal cell function. They react with sensitive cell materials, such as DNA, causing cell damage. The free radical theory of aging is that the accumulation of cell damage over time leads to eventual aging and death. If this theory is correct, then free radical damage (and thus aging) begins whenever the cells of the developing embryo start to use oxygen. While recovery from free radical damage appears possible from computer modeling of biblical lifespan data, the recovery is slow. Therefore, the best cure for aging is to prevent the cellular damage from occurring in the first place.
Pregnant or Breast-Feeding Women

Pregnancy is a sensitive time for the developing baby, and the newness of the discovery of MePiA makes it difficult to make recommendations about its use during pregnancy or lactation. While multiple women have consumed MePA during pregnancy and lactation with positive results (see the Testimonials by Esther, Erica, and Rachel), there are currently no reports from women consuming MePiA during pregnancy or lactation. Because of this, at present, each individual woman must decide for herself whether to take Dr. Aardsma’s Anti-Aging Vitamins during pregnancy or lactation. Women who are or may become pregnant are encouraged to discuss Dr. Aardsma’s Anti-Aging Vitamins supplementation with their physician prior to use, as is recommended for all nutritional supplements. ARP’s goal is to provide women who are or may become pregnant or are lactating with the best current information available to make an intelligent, informed choice regarding their use of these vitamins. Here are factors affecting this decision at present:

  1. The intake levels given in Table 1 are mathematical output using the assumptions that women pre-Flood were consuming water which contained MePA and MePiA, and that pregnant and lactating women pre-Flood had increased water intake similar to pregnant and lactating women today.
  2. Computer modeling of biblical lifespan data from Genesis shows that reversal of physiological aging is possible, and happened to Noah at a calculated rate of 1 year’s worth of physiological aging repaired every 12 years of adequate intake of the anti-aging vitamins (see Aging: Cause & Cure for details). Therefore, it is possible that any cellular damage occurring to a gestating or nursing baby (or the baby’s mother during the pregnancy or lactation) will be repaired over time via intake of MePA and MePiA later in life. Unfortunately, substantial epidemiological research over many years will likely be required to determine if there are health implications associated with the lack of maternally-derived anti-aging vitamins in the early years of a person’s life.
  3. The safety of MePA is well documented by ARP and other scientists. While less is known about MePiA, it has been tested by ARP for safety in animals and humans, and there is currently no indication of harm at any intake level. This includes laboratory animals consuming MePiA daily for months at a time in drinking water at approximately 10,000 to 100,000 times more MePiA per unit of body weight than the intakes given in Table 1.
  4. The theory supporting the idea that women pre-Flood consumed MePiA and MePA in drinking water is quite strong. Therefore, it appears that all people born before the Flood were born to mothers who were consuming MePA and MePiA. People born before the Flood lived much longer on average than people live today. It is possible that part of pre-Flood longevity was due to benefits to individuals associated with receiving MePA and MePiA from their mothers during their early developmental years (i.e., placental transfer and breast-milk transfer).
  5. As discussed above, in the “Children And Teens” section, if the free radical theory behind the effectiveness of Dr. Aardsma’s Anti-Aging Vitamins is correct, then there will be a benefit to the cells of the developing baby from the time the first developing cell begins to metabolize maternally-derived nutrients. Also, if the free radical theory is correct, then women who do not supplement with Dr. Aardsma’s Anti-Aging Vitamins during pregnancy will continue to experience free radical cellular damage at non-reduced rate for as long as they are not supplementing.
  6. Esther, the first woman known to consume MePA during pregnancy, used a common sense strategy of taking a very small amount of MePA (1 microgram) per day. Low levels of even acutely toxic compounds can often be safely ingested during pregnancy. As discussed in the February 26 update, it is believed that pregnant women can safely consume 1.5 cups of coffee per day, which is an intake of about 200,000 micrograms per day of an acutely toxic compound (caffeine). MePiA shows no evidence of being even mildly toxic, and the calculated pre-Flood intake of MePiA from Table 1 is quite small compared to the amount of caffeine in a cup of coffee.


ARP is encouraged by its recent theoretical and experimental progress toward the eventual eradication of the disease of human aging. It is hoped that the information in this update will help individuals make the best use of this progress to achieve healthier, longer lives through informed use of Dr. Aardsma’s Anti-Aging Vitamins.

ARP continues to work to determine the optimal daily intake for MePA and MePiA. Updated information will be posted here as it becomes available.

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